Many treatments exist, but they do not work in all people with neuropathic pain.

Drugs over the counter are not very useful, while those prescribed by doctors include tricyclic antidepressants (amitriptyline, desipramine, etc.); antiepileptics (carbamazepine, valproic acid, gabapentin, pregabalin etc); duloxetine, a serotonin-norepinephrine reuptake inhibitor; local anesthetic type of drugs (e.g. mexiletine); anti-inflammatory drugs (usually not very effective), opioids (morphine and similar drugs), and an approved oral spray derived from marijuana. Non-drug treatments are nerve, root and spinal cord blocks; local heat, cold or TENS, acupuncture and exercises; and finally surgery (spinal stimulators or implanted pumps and sometimes procedures like cutting or burning nerves).

Chronic pain takes its toll on a patient’s emotional and mental state, creating depression, sleep problems, isolation, loss of work and pride and problems with loved ones. The best way to treat chronic pain in general is a "whole person" approach and may require combination of medical and non-medical treatments (like counseling, relaxation and cognitive/behavioural techniques).